December 1999

The top 200 drugs of 1999

An exclusive report from IMS Health on the top 200 Rx
products, and the top 100 new scripts and refills

Spurred on by an increase in consumption and the introduction of innovative new therapies, prescription drug usage in Canada is on track to log another year of strong growth in 1999. Prior to 1998, the volume of prescription drugs dispensed throughout Canadian pharmacies grew at a fairly steady rate of between two and four per cent annually. In 1998 growth exceeded five per cent and will likely rise even higher again this year, thanks to new therapies to help treat a variety of conditions from arthritis to smoking cessation to sexual dysfunction.

For the 12 months ending September 1999, the volume of prescription drugs dispensed throughout Canadian retail pharmacies grew by over six per cent compared to the 12 months ending September 1998. Nearly 266 million prescriptions were dispensed throughout Canadian retail drugstores, compared to just over 250 million recorded for the same time frame last year.

While the top three products remain unchanged, their rankings have shifted over the past several years with a new number-one product emerging: Synthroid, the hypothyroidism therapy from Knoll. The formerly long-standing most-prescribed Tylenol with Codeine-3 from Ortho, which was ousted from top spot by Wyeth-Ayerst’s Premarin last year, this year dropped to number three (again behind Premarin).

New to the top 10 this year are SB Pharma’s antidepressant Paxil (# 8) and Parke-Davis’ cholesterol reducer Lipitor (#9), which jumped from the number-31 spot last year. Once again this year, the top 10 products accounted for roughly 13 per cent of all prescriptions dispensed.

The turnover of Top-200 prescription products is as active as ever, with this year’s list including 23 drugs that didn’t appear on last year’s list and 41 products that weren’t on the Top 200 list two years ago. Newcomers included
the highly successful arthritis treatment from Searle, Celebrex, which soared to the 53rd position after only six months of prescription activity. Also launched this year and making the list at 185th position is the erectile dysfunction therapy Viagra from Pfizer.

Other notable rises in the ranks included Glaxo Wellcome’s Zyban (716th in 1998 to 66th position in 1999), Merck’s Fosamax (from 135th to 72nd), P&G Pharma’s Didrocal (from 140th to 77th), Wyeth-Ayerst’s Alesse (409th to 78th), Lilly’s Zyprexa (197th to 107th) and Solvay Kingswood’s Pantoloc (240th to 116th).

Roughly four in every 10 (40.8%) prescriptions dispensed were for a generic product, a relatively stable proportion compared to last year. And as with last year, the list of the 50 most-prescribed generic products was dominated by Apotex (21 of the top 50) and Novopharm (20 of the top 50).

Slightly more prescriptions dispensed in the 12 months to September 1999 were for refills compared to new prescriptions (55% versus 45%, respectively), representing virtually no change from last year. The top refill prescribed was for Premarin; the number-one new prescription was for Tylenol with codeine-3.

This year’s list includes 23 drugs that weren’t on last year’s list, and 41 products that weren’t in the Top 200 two years ago

ABOUT IMS HEALTH

The information for this article was obtained from IMS Health Canada’s Canadian CompuScript Audit database. The CompuScript audit measures the number of prescriptions dispensed by retail pharmacies throughout Canada. The sample of 2,000 stores for this audit are drawn from the IMS Health panel of over 4,500 drugstores and is stratified by pharmacy type (chain, independent), size (small, medium, large) and by province.

IMS HEALTH is the world’s leading provider of health information and technology solutions for the pharmaceutical and healthcare industries, with offices in over 90 countries. For over three decades, IMS Health Canada has provided critical data and global intelligence on diagnosis, pharmaceutical consumption, disease patterns and treatment, along with decision support systems to the healthcare community. IMS processes nearly 300 million data transactions yearly from over 65,000 sources nationwide, and provides employment for over 300 professionals in Montreal and Toronto.

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THE TOP 200 RX PRODUCTS
Rank 1999* Rank 1998** Product Manufacturer % change***
1 3 SYNTHROID Knoll 14.8
2 1 PREMARIN Wyeth-Ayerst Canada 5.4
3 2 TYLENOL W/COD #3 Ortho 6.3
4 5 NOVASEN Novopharm 7.2
5 7 LOSEC AstraZeneca 11.3
6 4 NOVAMOXIN Novopharm -18
7 6 VASOTEC Frosst -11.3
8 12 PAXIL SB Pharma 23.2
9 31 LIPITOR Parke-Davis 90
10 9 ATIVAN Wyeth-Ayerst Canada 3.2
11 8 TRIPHASIL Wyeth-Ayerst Canada -9.3
12 13 NORVASC Pfizer 22.4
13 11 APO-AMOXI Apotex 9.5
14 10 LANOXIN Glaxo Wellcome -2.4
15 17 COUMADIN Dupont Pharmaceutical 12.8
16 14 ADALAT XL Bayer Pharma -0.6
17 15 ELTROXIN Glaxo Wellcome 0.2
18 21 ZOLOFT Pfizer 20.8
19 18 ZOCOR Frosst 7.2
20 16 SALBUTAMOL AltiMed -0.9
21 25 BIAXIN Abbott 21
22 19 PRAVACHOL Bristol-Myers Squibb 4.3
23 22 APO-FUROSEMIDE Apotex 11.9
24 26 APO-LORAZEPAM Apotex 16.9
25 40 FLOVENT Glaxo Wellcome 46.4
26 23 APO-SALVENT Apotex 5.4
27 29 ARTHROTEC Searle 12.4
28 28 CIPRO Bayer Pharma 10.5
29 20 NOVO-SALMOL Novopharm -9.1
30 27 APO-RANITIDINE Apotex 6.6
31 44 TRI-CYCLEN Ortho 33.4
32 32 C.E.S. ICN Canada 9.4
33 36 APO-HYDRO Apotex 16.1
34 24 NOVO-LORAZEM Novopharm -10.3
35 39 APO-AMITRIPTYLINE Apotex 14.6
36 30 NOVO-SEMIDE Novopharm -5.3
37 41 NITRO-DUR Schering 11.3
38 43 MARVELON Organon 12.3
39 42 NOVO-METFORMIN Novopharm 9.5
40 38 FLONASE Glaxo Wellcome 3.3
41 45 NOVO-HYDRAZIDE Novopharm 8.7
42 33 NOVO-RANIDINE Novopharm -6.6
43 35 PREPULSID Janssen -3
44 37 ATROVENT Boehringer Ingelheim -5.3
45 34 PROVERA Pharmacia & Upjohn -8
46 52 MONOPRIL Bristol-Myers Squibb 16.7
47 49 ZESTRIL AstraZeneca 9.4
48 51 APO-OXAZEPAM Apotex 10.3
49 47 KENRAL-MPA AltiMed -0.7
50 60 APO-PREDNISONE Apotex 21.4
51 46 MSD E.C. ASA J & J Merck Consumer -4.9
52 53 CORTATE Schering 4.3
53 N/A CELEBREX Searle N/A
54 67 COZAAR Frosst 27.9
55 61 APO-GLYBURIDE Apotex 8.4
56 75 APO-ATENOL Apotex 26.5
57 55 TYLENOL W/COD #2 Ortho -0.9
58 56 DILANTIN SODIUM Parke-Davis 0.3
59 93 APO-DILTIAZ CD Apotex 43.8
60 71 ACCUPRIL Parke-Davis 19.6
61 62 APO-NAPROXEN Apotex 5.1
62 48 ORTHO 7/7/7 Ortho -18
63 95 ZITHROMAX Pfizer 39.5
64 64 PULMICORT AstraZeneca 3
65 50 ALTI-DILTIAZEM CD AltiMed -15.6
66 716 ZYBAN Glaxo Wellcome N/A
67 65 PRINIVIL Frosst 2.7
68 59 NOVO-METOPROL Novopharm -7.8
69 58 ESTRADERM Novartis -9.8
70 63 NOVO-TRIPTYN Novopharm -6
71 68 LIPIDIL MICRO Fournier 2.2
72 135 FOSAMAX Merck Sharp & Dohme 62.9
73 115 ALTACE Hoechst Marion Roussel 44.6
74 81 GEN-GLYBE Genpharm 10.4
75 131 GEN-METFORMIN Genpharm 54.8
76 111 RISPERDAL Janssen 34.2
77 140 DIDROCAL P&G Pharma 61.5
78 409 ALESSE Wyeth-Ayerst Canada 394.6
79 57 NOVO-PEN-VK Novopharm -16.1
80 122 NOVO-MEDRONE Novopharm 45.2
81 79 NITROLINGUAL RPR Ethical 4.5
82 77 APO-DIAZEPAM Apotex 4.1
83 96 EPIVAL Abbott 19.7
84 54 BECLOFORTE Glaxo Wellcome -21.4
85 76 FUCIDIN Leo 2.4
86 83 CEFTIN Glaxo Wellcome 7.5
87 72 NOVOXAPAM Novopharm -3.1
88 74 NAPROSYN E Roche -1.8
89 78 APO-ACETAMINOPHEN Apotex 1.8
90 70 NOVO-GLYBURIDE Novopharm -5.2
91 100 APO-CLONAZEPAM Apotex 19.8
92 106 OXYCOCET Technilab 22.2
93 80 NOVO-TRIAMZIDE Novopharm -0.7
94 66 NOVO-LEXIN Novopharm -12.5
95 134 PROMETRIUM Schering 41.2
96 89 HUMULIN N Lilly 4.5
97 84 APO-TEMAZEPAM Apotex -1.9
98 91 GARASONE Schering 4.6
99 86 APO-SULFATRIM DS Apotex 1.4
100 85 LOZIDE Servier Lab -0.3
101 105 ELOCOM Schering 14.4
102 73 CYCLEN Ortho -11.1
103 69 MIN-OVRAL Wyeth-Ayerst Canada -14.4
104 118 APO-METOPROLOL-L Apotex 23.3
105 124 APO-TRIAZIDE Apotex 25.5
106 151 PREVACID Abbott 49.1
107 197 ZYPREXA Lilly 83.8
108 103 LAMISIL Novartis 8.5
109 97 NOVO-PREDNISONE Novopharm 2.4
110 113 CELESTODERM-V Schering 13
111 112 PMS-CLONAZEPAM-R Pharmascience 12.9
112 87 NOVO-NAPROX Novopharm -4.4
113 101 NOVO-ATENOL Novopharm 4.5
114 88 ECTOSONE Technilab -6.3
115 90 NOVO-GESIC Novopharm -4.7
116 240 PANTOLOC Solvay Kingswood 108.3
117 114 APO-PEN-VK Apotex 9.9
118 120 APO-IBUPROFEN Apotex 14.5
119 167 COMBIVENT Boehringer Ingelheim 49.4
120 99 IMITREX Glaxo Wellcome -2.3
121 82 PMS-FLUOXETINE Pharmascience -16.2
122 104 APO-ALLOPURINOL Apotex -0.8
123 110 RHOVANE Rhodiapharm 1.9
124 108 APO-LOVASTATIN Apotex 0.4
125 107 CLAVULIN SB Pharma -0.3
126 102 TRIQUILAR Berlex Canada -2.3
127 139 SERZONE Bristol-Myers Squibb 22
128 121 APO-ALPRAZ Apotex 9.8
129 125 NOVO-PUROL Novopharm 10.3
130 128 OGEN Pharmacia & Upjohn 11.6
131 94 VENTOLIN Glaxo Wellcome -13.3
132 141 APO-ZOPICLONE Apotex 14.9
133 92 BECLOMETHASONE AltiMed -17.5
134 194 GEN-RANITIDINE Genpharm 47.2
135 206 LIN-AMOX Linson 50.9
136 117 APO-ERYTHRO EC Apotex -3.6
137 808 EFFEXOR XR Wyeth-Ayerst Canada 856.5
138 213 ESTRACE Roberts Pharma 50.3
139 145 GARAMYCIN Schering 10
140 130 TRUSOPT Merck Sharp & Dohme -3.1
141 142 MPRACET-30 Glaxo Wellcome 3.3
142 162 DIFLUCAN-150 Pfizer 18.6
143 133 ZOVIRAX Glaxo Wellcome -3.6
144 119 NOVO-DIPAM Novopharm -11.2
145 180 DALACIN C Pharmacia & Upjohn 25.9
146 171 APO-METFORMIN Apotex 19.2
147 149 BRICANYL AstraZeneca 2.9
148 207 INHIBACE Roche 33.3
149 159 SENOKOT Purdue Frederick 8.8
150 178 IMOVANE RPR Ethical 17.5
151 123 NOVO-CLOXIN Novopharm -15.6
152 228 GEN-MEDROXY Genpharm 40.4
153 163 NOVOLIN GE NPH Novo Nordisk 5
154 150 SULAMYD Schering -3.8
155 217 COVERSYL Servier Lab 31.6
156 165 PMS-CLONAZEPAM Pharmascience 3.5
157 176 APO-FLUOXETINE Apotex 9.7
158 220 APO-CEFACLOR Apotex 32.1
159 153 NOVO-TETRA Novopharm -2.3
160 138 NOVO-CYCLOPRINE Novopharm -14.3
161 148 NU-AMOXI Nu-Pharm Inc. -7.1
162 170 RENEDIL Hoechst Marion Roussel 4.3
163 160 APO-ACEBUTOLOL Apotex 0.3
164 146 LOESTRIN 1.5/30 Parke-Davis -8.8
165 154 HUMULIN R Lilly -3.6
166 276 CEFZIL Bristol-Myers Squibb 60.6
167 894 WELLBUTRIN Glaxo Wellcome 842.3
168 129 ORTHO-CEPT Ortho -21
169 143 LESCOL Novartis -12.2
170 137 NOVO-TRIMEL DS Novopharm -17.9
171 205 NOVO-PROFEN Novopharm 15.3
172 126 EFFEXOR Wyeth-Ayerst Canada -22.8
173 168 EMTEC-30 Technilab 0.1
174 234 BIAXIN PEDIATRIC Abbott 32
175 238 NASACORT AQ RPR Ethical 31.3
176 132 NOVO-DIFENAC Novopharm -20.6
177 144 CYTOTEC Searle -13.3
178 156 APO-BENZTROPINE Apotex -7.6
179 192 APO-CEPHALEX Apotex 7.3
180 158 SYNPHASIC Searle -5.6
181 177 PMS-METHYLPHENIDAT Pharmascience 1.2
182 352 XALATAN Pharmacia & Upjohn 109.2
183 166 BETOPTIC S Alcon -5.8
184 169 PONDOCILLIN Leo -5.3
185 N/A VIAGRA Pfizer N/A
186 175 APO-AMILZIDE Apotex -2.9
187 193 WESTCORT Westwood Squibb 3.1
188 188 APO-SULFATRIM Apotex 2
189 201 PLENDIL AstraZeneca 6.1
190 185 DEMEROL Sanofi -0.6
191 196 PMS-TEMAZEPAM Novartis 3.2
192 222 K-DUR 20 Schering 15.7
193 202 GEN-INDAPAMIDE Genpharm 4
194 200 NOVOLIN GE 30/70 Novo Nordisk 3.5
195 172 NAXEN AltiMed -7.3
196 182 DEMULEN 30 Searle -3.2
197 215 LOPRESOR SR Novartis 11.1
198 155 TENORMIN AstraZeneca -15.2
199 173 GEN-VERAPAMIL SR Genpharm -7.6
200 232 PMS-LITHIUM CARBON Pharmascience 17.1

Copyright IMS HEALTH ** For 12 months ending September 1998

* For 12 months ending September 1999 *** % change from 12 months ending Sept 98 to 12 months ending Sept 99

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THE TOP 100 NEW RX PRODUCTS
Rank 1999* Rank 1998** Product Manufacturer % change***
1 1 TYLENOL W/COD #3 Ortho 9.8
2 2 NOVAMOXIN Novopharm -16.8
3 3 APO-AMOXI Apotex 8.7
4 4 BIAXIN Abbott 22
5 5 SYNTHROID Knoll 14.1
6 6 PREMARIN Wyeth-Ayerst Canada 2.1
7 7 CIPRO Bayer Pharma 11.8
8 8 LOSEC AstraZeneca 6.9
9 10 PAXIL SB Pharma 18.6
10 9 ATIVAN Wyeth-Ayerst Canada 3.4
11 26 FLOVENT Glaxo Wellcome 44
12 13 ARTHROTEC Searle 9.6
13 18 ZOLOFT Pfizer 16
14 32 ZITHROMAX Pfizer 40.2
15 14 SALBUTAMOL AltiMed 3.6
16 15 NOVASEN Novopharm 6.7
17 17 CORTATE Schering 5
18 11 VASOTEC Frosst -13.5
19 52 LIPITOR Parke-Davis 63.8
20 23 COUMADIN Dupont Pharmaceutical 11.9
21 21 APO-SALVENT Apotex 8.5
22 16 NOVO-SALMOL Novopharm -6.1
23 28 APO-LORAZEPAM Apotex 17.8
24 N/A CELEBREX Searle N/A
25 12 NOVO-PEN-VK Novopharm -15.1
26 24 CEFTIN Glaxo Wellcome 7.7
27 20 FLONASE Glaxo Wellcome -1.7
28 34 APO-PREDNISONE Apotex 20.1
29 33 NORVASC Pfizer 17.8
30 19 NOVO-LEXIN Novopharm -12
31 27 APO-NAPROXEN Apotex 5.8
32 31 TYLENOL W/COD #2 Ortho 4.5
33 29 FUCIDIN Leo 2
34 30 APO-SULFATRIM DS Apotex 1.4
35 22 TRIPHASIL Wyeth-Ayerst Canada -10.9
36 36 GARASONE Schering 5.2
37 462 ZYBAN Glaxo Wellcome 941.3
38 25 NOVO-LORAZEM Novopharm -9.5
39 37 APO-RANITIDINE Apotex 6
40 35 ELTROXIN Glaxo Wellcome 3.4
41 43 APO-AMITRIPTYLINE Apotex 12.4
42 42 APO-PEN-VK Apotex 9.7
43 47 APO-FUROSEMIDE Apotex 12.7
44 39 CLAVULIN SB Pharma 0.4
45 45 ADALAT XL Bayer Pharma 3.2
46 38 NAPROSYN E Roche -3.3
47 41 LANOXIN Glaxo Wellcome -1.8
48 58 APO-HYDRO Apotex 20.1
49 61 OXYCOCET Technilab 25.8
50 46 APO-ERYTHRO EC Apotex -3.7
51 50 ZOCOR Frosst 4.3
52 51 EMPRACET-30 Glaxo Wellcome 3.2
53 60 ELOCOM Schering 14.3
54 44 NOVO-RANIDINE Novopharm -8.8
55 63 CELESTODERM-V Schering 14.5
56 54 PRAVACHOL Bristol-Myers Squibb -0.7
57 53 NOVO-NAPROX Novopharm -1.6
58 95 LIN-AMOX Linson 48.1
59 64 GARAMYCIN Schering 11.6
60 66 NITROLINGUAL RPR Ethical 11.1
61 87 TRI-CYCLEN Ortho 39
62 49 PREPULSID Janssen -8.5
63 72 APO-IBUPROFEN Apotex 12.7
64 69 LAMISIL Novartis 10
65 81 DALACIN C Pharmacia & Upjohn 26.5
66 48 NOVO-CLOXIN Novopharm -15.1
67 74 NOVO-HYDRAZIDE Novopharm 9.4
68 67 NOVO-PREDNISONE Novopharm 3.3
69 57 ECTOSONE Technilab -5.2
70 71 PULMICORT AstraZeneca 4.7
71 59 NU-AMOXI Nu-Pharm Inc. -6.8
72 70 EMTEC-30 Technilab 0
73 68 SULAMYD Schering -3.4
74 123 CEFZIL Bristol-Myers Squibb 60.2
75 62 NOVO-SEMIDE Novopharm -5.4
76 103 APO-CEFACLOR Apotex 35
77 79 APO-OXAZEPAM Apotex 11.4
78 104 IAXIN PEDIATRIC Abbott 33
79 84 C.E.S. ICN Canada 13
80 78 NITRO-DUR Schering 7.3
81 94 DIFLUCAN-150 Pfizer 17.1
82 80 APO-CEPHALEX Apotex 6.7
83 98 MARVELON Organon 19.6
84 56 NOVO-TRIMEL DS Novopharm -17.3
85 73 PONDOCILLIN Leo -5.2
86 75 ATROVENT Boehringer Ingelheim -5
87 91 NOVO-METFORMIN Novopharm 12.5
88 76 ZOVIRAX Glaxo Wellcome -1.9
89 89 APO-DIAZEPAM Apotex 2.2
90 105 MONOPRIL Bristol-Myers Squibb 13.3
91 92 APO-SULFATRIM Apotex 0.3
92 102 ZESTRIL AstraZeneca 9.4
93 82 NOVO-TRIPTYN Novopharm -7
94 96 APO-CLOXI Apotex 0.6
95 85 KENRAL-MPA AltiMed -7.2
96 99 DEMEROL Sanofi 0.9
97 97 RHOVANE Rhodiapharm -1.1
98 120 NOVO-PROFEN Novopharm 20.3
99 110 APO-ZOPICLONE Apotex 8.9
100 86 NOVO-CYCLOPRINE Novopharm -11.6

Copyright IMS HEALTH ** For 12 months ending September 1998

* For 12 months ending September 1999 *** % change from 12 months ending Sept 98 to 12 months ending Sept 99

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THE TOP 100 REFILL SCRIPTS
Rank 1999* Rank 1998** Product Manufacturer % change***
1 1 PREMARIN Wyeth-Ayerst Canada 6.5
2 2 SYNTHROID Knoll 15
3 3 NOVASEN Novopharm 7.3
4 6 LOSEC AstraZeneca 13.6
5 4 VASOTEC Frosst -10.5
6 5 TRIPHASIL Wyeth-Ayerst Canada -8.8
7 24 LIPITOR Parke-Davis 102.6
8 10 NORVASC Pfizer 24.1
9 7 LANOXIN Glaxo Wellcome -2.5
10 15 PAXIL SB Pharma 26.8
11 9 ATIVAN Wyeth-Ayerst Canada 3
12 8 ADALAT XL Bayer Pharma -1.8
13 12 ZOCOR Frosst 8.2
14 11 ELTROXIN Glaxo Wellcome -1.1
15 14 COUMADIN Dupont Pharmaceutical 13.2
16 13 PRAVACHOL Bristol-Myers Squibb 5.9
17 18 APO-FUROSEMIDE Apotex 11.5
18 16 TYLENOL W/COD #3 Ortho -4.4
19 23 ZOLOFT Pfizer 24.5
20 17 SALBUTAMOL AltiMed -3.9
21 19 C.E.S. ICN Canada 8.3
22 26 APO-LORAZEPAM Apotex 16.4
23 36 TRI-CYCLEN Ortho 31.3
24 30 MARVELON Organon 9.9
25 25 APO-SALVENT Apotex 3.2
26 32 NITRO-DUR Schering 12.9
27 20 NOVO-SEMIDE Novopharm -5.3
28 35 APO-HYDRO Apotex 14.1
29 31 NOVO-METFORMIN Novopharm 8.4
30 28 APO-RANITIDINE Apotex 7
31 21 PROVERA Pharmacia & Upjohn -7.1
32 22 NOVO-SALMOL Novopharm -11.3
33 56 FLOVENT Glaxo Wellcome 49
34 29 ATROVENT Boehringer Ingelheim -5.4
35 27 NOVO-LORAZEM Novopharm -10.9
36 39 NOVO-HYDRAZIDE Novopharm 8.4
37 46 MONOPRIL Bristol-Myers Squibb 18
38 34 MSD E.C. ASA J & J Merck Consumer -3
39 42 ZESTRIL AstraZeneca 9.5
40 45 APO-AMITRIPTYLINE Apotex 16.3
41 38 PREPULSID Janssen 0.2
42 41 KENRAL-MPA AltiMed 2.1
43 37 NOVO-RANIDINE Novopharm -5.2
44 48 ARTHROTEC Searle 15.8
45 58 COZAAR Frosst 32.3
46 44 DILANTIN SODIUM Parke-Davis 0
47 49 APO-OXAZEPAM Apotex 9.7
48 47 APO-GLYBURIDE Apotex 7.8
49 69 APO-DILTIAZ CD Apotex 48.2
50 33 ORTHO 7/7/7 Ortho -18.8
51 40 ALTI-DILTIAZEM CD AltiMed -14.6
52 62 APO-ATENOL Apotex 25.3
53 43 ESTRADERM Novartis -10
54 60 ACCUPRIL Parke-Davis 18.8
55 55 LIPIDIL MICRO Fournier 5.1
56 91 FOSAMAX Merck Sharp & Dohme 67.5
57 53 PRINIVIL Frosst 3.1
58 61 FLONASE Glaxo Wellcome 9.9
59 50 NOVO-METOPROL Novopharm -8.6
60 59 HUMULIN N Lilly 3.5
61 57 NOVO-GLYBURIDE Novopharm -4.9
62 66 GEN-GLYBE Genpharm 8.2
63 106 GEN-METFORMIN Genpharm 59.4
64 97 NOVO-MEDRONE Novopharm 51.9
65 52 MIN-OVRAL Wyeth-Ayerst Canada -15.5
66 92 ALTACE Hoechst Marion Roussel 41.8
67 64 NOVO-TRIAMZIDE Novopharm 0.3
68 54 CYCLEN Ortho -12
69 80 EPIVAL Abbott 22.7
70 51 BECLOFORTE Glaxo Wellcome -20.5
71 402 ALESSE Wyeth-Ayerst Canada 577.1
72 67 APO-ACETAMINOPHEN Apotex 1.8
73 68 LOZIDE Servier Lab 0
74 63 NOVO-TRIPTYN Novopharm -5.4
75 93 RISPERDAL Janssen 38.1
76 65 NOVOXAPAM Novopharm -1.5
77 95 PROMETRIUM Schering 40.8
78 122 DIDROCAL P&G Pharma 69.8
79 88 APO-METOPROLOL-L Apotex 22
80 90 APO-CLONAZEPAM Apotex 21.7
81 73 APO-LOVASTATIN Apotex 2.8
82 75 NOVO-ATENOL Novopharm 4.5
83 72 PULMICORT AstraZeneca 1.4
84 94 APO-TRIAZIDE Apotex 26.1
85 70 TRIQUILAR Berlex Canada -3.4
86 89 OGEN Pharmacia & Upjohn 13.9
87 71 NOVO-GESIC Novopharm -3.7
88 81 APO-DIAZEPAM Apotex 5.7
89 76 TRUSOPT Merck Sharp & Dohme -0.8
90 77 APO-ALLOPURINOL Apotex -0.8
91 78 IMITREX Glaxo Wellcome -1.4
92 79 APO-TEMAZEPAM Apotex -0.7
93 168 ZYPREXA Lilly 94.6
94 87 NOVO-PUROL Novopharm 5.8
95 130 COMBIVENT Boehringer Ingelheim 51.9
96 110 APO-PREDNISONE Apotex 23.8
97 103 PMS-CLONAZEPAM-R Pharmascience 14.3
98 138 PREVACID Abbott 58.8
99 74 PMS-FLUOXETINE Pharmascience -14.2
100 241 PANTOLOC Solvay Kingswood 147.7

Copyright IMS HEALTH ** For 12 months ending September 1998

* For 12 months ending September 1999 *** % change from 12 months ending Sept 98 to 12 months ending Sept 99